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Children with obstructive snooze apnea who will be addressed with codeine for put up-tonsillectomy and/or adenoidectomy discomfort could possibly be particularly sensitive to its respiratory depressant impact; as a consequence of chance of daily life-threatening respiratory despair and Loss of life: codeine is contraindicated in all children young than 12 many years of age; Additionally it is contraindicated for submit-operative management in pediatric sufferers young than 18 a long time of age following tonsillectomy and/or adenoidectomy
chloroquine will raise the level or impact of codeine by influencing hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor. Helps prevent conversion of codeine to its Energetic metabolite morphine.
Get this medication by mouth with or with out foodstuff that has a total glass of drinking water (eight ounces or 240 milliliters) or as directed by your medical professional. This medication might be taken with meals or milk if abdomen upset occurs. The dosage is based on your own health-related ailment and reaction to treatment.
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The chance for intense respiratory problems is increased when You begin this medication, or if you're taking the incorrect dose or acquire a lot more of the medication than prescribed. Taking this medication with alcohol or other drugs that might cause drowsiness or respiratory complications could induce extremely really serious Unwanted side effects, including Loss of life. Also, other medications can have an impact on the elimination of the solution from your entire body, which can influence how it works.
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buprenorphine, extensive-acting injection and codeine both equally raise sedation. Keep away from or Use Alternate Drug. Restrict use to more info people for whom alternate remedy alternatives are insufficient
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Dosage really should not be enhanced if cough fails to reply; an unresponsive cough needs to be reevaluated in five days or sooner for achievable fundamental pathology, such as overseas system or lower respiratory tract condition
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